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Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations.

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第一作者: Vickram,Tejwani
第一单位: Department of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA. Tejwanv@ccf.org.;Department of Genomic Science and Systems Biology, Cleveland Clinic, Cleveland, OH, USA. Tejwanv@ccf.org.
作者单位: Department of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA. Tejwanv@ccf.org.;Department of Genomic Science and Systems Biology, Cleveland Clinic, Cleveland, OH, USA. Tejwanv@ccf.org. [1] Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA. [2] Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. [3] Division of Allergy, Immunology and Infectious Disease, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [4] Division of Allergy and Immunology, Johns Hopkins University, Baltimore, MD, USA. [5] Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. [6] Division of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, CA, USA. [7] Department of Pulmonary and Critical Care Medicine, Integrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH, USA.;Department of Genomic Science and Systems Biology, Cleveland Clinic, Cleveland, OH, USA. [8] Division of Pulmonary, Critical Care, and Occupational Medicine, College of Medicine, University of Iowa, Iowa City, IA, USA. [9] Department of Biostatistics, Gillings School of Global Public Health, Chapel Hill, NC, USA. [10] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA. [11] Departments of Medicine and Genomic Medicine, Weill-Cornell College of Medicine, New York, NY, USA. [12] Chicago Center, Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois Chicago, Chicago, IL, USA. [13] Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. [14] Division of Pulmonary and Critical Care Medicine, University of Massachusetts, Wooster, MA, USA. [15] Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, NC, USA. [16] Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [17] Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Scottsdale, AZ, USA. [18] Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah School of Medicine, Salt Lake City, USA. [19] Centre for Gene Therapeutics, CSL Behring, Berne, Switzerland. [20] Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA. [21] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.;Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.;Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, USA. [22] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.;Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA. [23] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.;Research Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.;Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA. [24]
DOI 10.1186/s12931-025-03310-w
PMID 40682114
发布时间 2026-03-06
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