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Machine learning-assisted tacrolimus dose optimization in childhood- onset systemic lupus erythematosus through population pharmacokinetic modeling.

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第一作者： Heng,Liang

第一单位： National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.

作者： Heng,Liang ^[1] ; Qiaolan,Xuan ^[1] ; Chuwei,Liu ^[2] ; Arabella,Wan ^[3] ; Nan,You ^[1] ; Min,Xiao ^[1] ; Heteng,Zhang ^[1] ; Minzhen,Han ^[4] ; Guohui,Wan ^[5]

作者单位： National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. ^[1] Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. ^[2] Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. ^[3] Department of Pharmacy, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, 556000, China. ^[4] National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, National Engineering Research Center for New Drug and Druggability (cultivation), Guangdong Province Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: wanguoh@mail.sysu.edu.cn. ^[5]