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Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.

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第一作者： Muting,Qin

第一单位： Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.

作者： Muting,Qin ^[1] ; Penglu,Chen ^[1] ; Huanxue,Chen ^[1] ; Feng,Liu ^[2] ; Wei,He ^[3] ; Enyang,Yao ^[4]

作者单位： Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China. ^[1] Transportation Research Institute (IMOB), Hasselt University, Martelare Nlaan, 42-3500, Hasselt, Belgium. ^[2] Department of Thoracic Surgery, The Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China. ^[3] Department of Orthopedics, The Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China. ^[4]

关键词 Co-delivery nanosystem Emodin Fe-based metal-organic framework KEAP1 Macrophage polarization Rheumatoid arthritis

DOI 10.1016/j.mtbio.2025.102074

PMID 40688667

发布时间 2025-07-23

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Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.

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Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.

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