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PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease.

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第一作者： Claire Y,Chiang

第一单位： Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.

作者： Claire Y,Chiang ^[1] ; Neringa,Pratuseviciute ^[2] ; Yu-En,Lin ^[1] ; Ayan,Adhikari ^[1] ; Wondwossen M,Yeshaw ^[1] ; Chloe,Flitton ^[3] ; Pemba L,Sherpa ^[1] ; Francesca,Tonelli ^[3] ; Irena,Rektorova ^[4] ; Timothy,Lynch ^[5] ; Joanna,Siuda ^[6] ; Monika,Rudzińska-Bar ^[7] ; Oleksandr,Pulyk ^[8] ; Peter,Bauer ^[9] ; Christian,Beetz ^[9] ; Dennis W,Dickson ^[10] ; Owen A,Ross ^[10] ; Zbigniew K,Wszolek ^[10] ; Global Parkinson’s Genetics Program (GP2) ^[11] ; Zih-Hua,Fang ^[12] ; Christine,Klein ^[13] ; Alexander,Zimprich ^[3] ; Dario R,Alessi ^[3] ; Esther M,Sammler ^[14] ; Suzanne R,Pfeffer

作者单位： Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. ^[1] MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK. ^[2] Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, UK. ^[3] School of Medicine and St Anne's Hospital, 1st Department of Neurology, Pekarska 53, Brno, Czech Republic. ^[4] Department of Neurology, Dublin Neurological Institute, Dublin, Ireland. ^[5] Śląski Uniwersytet Medyczny w Katowicach, Katowice, Poland. ^[6] Department of Neurology, Andrzej Frycz Modrzewski University, Krakow, Poland. ^[7] Wladyslaw Bieganski Collegium Medicum Jan Długosz University, Częstochowa, Poland. ^[8] CENTOGENE GmbH, Rostock, Germany. ^[9] Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL 32224, USA. ^[10] German Center for Neurodegenerative Diseases, DZNE, Tübingen, Germany. ^[11] Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. ^[12] Department of Neurology, Medical University of Vienna, Vienna, Austria. ^[13] Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Electronic address: pfeffer@stanford.edu. ^[14]

关键词 CP: Cell biology CP: Neuroscience LRRK2 kinase Parkinson’s disease Rab GTPase phosphatase primary cilia