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In vitro transporter substrate properties of previously reported biomarkers for renal OAT1/OAT3-mediated drug-drug interactions.

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第一作者： Jana,Picurová

第一单位： Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

作者： Jana,Picurová ^[1] ; Arne,Gessner ^[2] ; Nora,Bartels ^[1] ; Sofie,Scheuerlein ^[1] ; Oliver,Fischer ^[3] ; Lena,Lochschmidt ^[3] ; Pia,Wenisch ^[3] ; Peter,Stopfer ^[4] ; Markus R,Heinrich ^[5] ; Jörg,König ^[2] ; Martin F,Fromm ^[6]

作者单位： Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[1] Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU NeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[2] Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[3] Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[4] FAU NeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Chemistry and Pharmacy, Pharmaceutical Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. ^[5] Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; FAU NeW - Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address: martin.fromm@fau.de. ^[6]

关键词 Biomarker Drug-drug interaction OAT1 OAT3 Renal elimination Transport proteins

医学主题词人类(Humans);有机阴离子转运蛋白1(Organic Anion Transport Protein 1);有机阴离子转运子, 非钠依赖(Organic Anion Transporters, Sodium-Independent);药物相互作用(Drug Interactions);肾(Kidney);HEK293细胞(HEK293 Cells);底物特异性(Substrate Specificity)

DOI 10.1016/j.bcp.2025.117184

PMID 40692107

发布时间 2025-09-16

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