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Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy.

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第一作者： Derek W,Brown

第一单位： Foundation Medicine, Inc., Boston, MA, USA.

作者： Derek W,Brown ^[1] ; Daokun,Sun ^[1] ; Alexander D,Fine ^[1] ; Shai,He ^[1] ; Michael,McDevitt ^[1] ; Kerriann,Pontbriand ^[1] ; Eliana,Polisecki ^[1] ; Angela,Kou ^[1] ; Mingyue,Li ^[1] ; Shumeng,Zhang ^[1] ; Zheng,Kuang ^[1] ; David,Fabrizio ^[1] ; Russell W,Madison ^[1] ; Jie,He ^[1] ; Zoe June,Assaf ^[2] ; Thomas,Powles ^[3] ; Christopher,Sweeney ^[4] ; David,Gandara ^[5] ; Emmanuel S,Antonarakis ^[6] ; Lee A,Albacker ^[1] ; Aparna,Aiyer ^[1] ; Bahar,Yilmazel ^[1] ; Brennan J,Decker ^[1] ; Jason D,Hughes ^[1] ; Hanna,Tukachinsky ^[1] ; Chang,Xu ^[1]

作者单位： Foundation Medicine, Inc., Boston, MA, USA. ^[1] Genentech, Inc., South San Francisco, CA, USA. ^[2] Barts Cancer Institute, Experimental Cancer Medicine Centre, Queen Mary University of London, St Bartholomew's Hospital, London, United Kingdom. ^[3] South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, Australia. ^[4] UC Davis Comprehensive Cancer Center, Sacramento, CA, USA. ^[5] University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA. ^[6]

关键词 Clonal hematopoiesis Comprehensive genomic profiling Fragmentomics Germline Monitoring ctDNA liquid biopsy

DOI 10.1016/j.jlb.2025.100311

PMID 40704056

发布时间 2025-07-28

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The journal of liquid biopsy

2025年9卷

100311页

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The journal of liquid biopsy

2025年9卷

100311页

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Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy.

The journal of liquid biopsy

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Fragmentomic-based algorithm to computationally predict tumor-somatic, germline, and clonal hematopoiesis variant origin in liquid biopsy.

The journal of liquid biopsy

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The journal of liquid biopsy

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