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Uncoupling toxic NO signaling: Progress, challenges, and therapeutic promise of disrupting the PSD-95/nNOS protein-protein interaction.

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第一作者： Emadeldin M,Kamel

第一单位： Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.

作者： Emadeldin M,Kamel ^[1] ; Ahmed A,Allam ^[2] ; Hassan A,Rudayni ^[3] ; Noha A,Ahmed ^[4] ; Faris F,Aba Alkhayl ^[5] ; Al Mokhtar,Lamsabhi ^[6]

作者单位： Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. ^[1] Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia. Electronic address: aallam@imamu.edu.sa. ^[2] Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia. ^[3] Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt. ^[4] Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia. ^[5] Departamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid, 28049, Madrid, Spain. ^[6]

关键词 Excitotoxicity Neuroprotection PSD-95 Protein-protein interaction inhibitors nNOS

医学主题词人类(Humans);一氧化氮合酶Ⅰ型(Nitric Oxide Synthase Type I);动物(Animals);信号传导(Signal Transduction);一氧化氮(Nitric Oxide);分子结构(Molecular Structure);小分子化合物库(Small Molecule Libraries)

DOI 10.1016/j.ejmech.2025.117994

PMID 40712457

发布时间 2025-09-02

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