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Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.

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第一作者： Arlette A,Kasongo

第一单位： Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.

作者： Arlette A,Kasongo ^[1] ; Viyashini,Vijithakumar ^[1] ; Khaled S,Abd-Elrahman ^[2] ; Radhika,Prabhune ^[1] ; Lara,Gharibeh ^[1] ; Rachel,Nadeau ^[3] ; Isabelle,Robillard ^[4] ; Shoshana,Spring ^[5] ; Sabrina,Robichaud ^[1] ; Shaza,Asif ^[1] ; Derrick,Gibbings ^[6] ; Kathryn J,Moore ^[7] ; John G,Sled ^[8] ; Matthieu,Ruiz ^[9] ; Mathieu,Lavallée-Adam ^[3] ; Stephen S G,Ferguson ^[10] ; Baptiste,Lacoste ^[10] ; Diane C,Lagace ^[10] ; Mireille,Ouimet ^[11]

作者单位： Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada. ^[1] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. ^[2] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON. ^[3] Montreal Heart Institute Research Center, Montreal, QC, Canada. ^[4] Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada. ^[5] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. ^[6] Department of Medicine, Cardiovascular Research Center, New York University School of Medicine, New York, NY. ^[7] Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. ^[8] Montreal Heart Institute Research Center, Montreal, QC, Canada; Département de Nutrition, Université de Montréal, Montreal, QC, Canada. ^[9] Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Brain and Mind Research Institute, Ottawa, ON, Canada. ^[10] Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada. Electronic address: mireille.ouimet@uottawa.ca. ^[11]

关键词 amyloid beta astrocyte cholesterol efflux high-density lipoprotein lipid droplet lipid metabolism oxysterol-binding protein-like 6