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Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ.

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第一作者： Rowan,Green

第一单位： School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, UK.;Department of Zoology, Faculty of Science, University of British Columbia, Vancouver, Canada.

作者： Rowan,Green ^[1] ; Huw,Richards ^[2] ; Deniz,Ozbilek ^[3] ; Francesca,Tyrrell ^[3] ; Victoria,Barton ^[3] ; Ziang,Zhang ^[3] ; Simon C,Lovell ^[3] ; Danna R,Gifford ^[3] ; Mato,Lagator ^[3] ; Andrew J,McBain ^[4] ; Rok,Krašovec ^[3] ; Christopher G,Knight ^[2]

作者单位： School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, UK.;Department of Zoology, Faculty of Science, University of British Columbia, Vancouver, Canada. ^[1] School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, UK. ^[2] School of Biological Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK. ^[3] School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK. ^[4]

关键词 NudJ Nudix RpoB anti-evolution drugs density associated mutation rate plasticity distribution of fitness effects mutation rate mutation rate plasticity mutational signature mutational spectrum rifampicin

医学主题词大肠杆菌(Escherichia coli);大肠杆菌蛋白质类(Escherichia coli Proteins);突变(Mutation);焦磷酸酶类(Pyrophosphatases);进化, 分子(Evolution, Molecular);遗传适合度(Genetic Fitness);生物进化(Biological Evolution)

DOI 10.1093/molbev/msaf182

PMID 40729517

发布时间 2025-08-26

基金项目

DTP BB/T008725/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom ::UK Research and Innovation:: MR/T021225/1/Future Leaders Fellowship

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