首页> Scientific reports> Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration.

Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration.

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第一作者： Nanami,Kishima

第一单位： Department of Chromosome Biomedical Engineering, Integrated Medical Sciences, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.

作者： Nanami,Kishima ^[1] ; Takashi,Moriwaki ^[2] ; Narumi,Uno ^[3] ; Teruhiko,Suzuki ^[4] ; Satoshi,Abe ^[5] ; Masaki,Sugawara ^[1] ; Yuichi,Nagashima ^[1] ; Kanako,Kazuki ^[5] ; Takeshi,Endo ^[6] ; Kyotaro,Yamazaki ^[7] ; Wakana,Nakagawa ^[1] ; Reika,Yuno ^[1] ; Yui,Moriguchi ^[1] ; Satoko,Matsukura ^[8] ; Kazuma,Tomizuka ^[3] ; Yasuhiro,Kazuki ^[9]

作者单位： Department of Chromosome Biomedical Engineering, Integrated Medical Sciences, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. ^[1] Department of Chromosome Biomedical Engineering, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. ^[2] Laboratory of Bioengineering, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. ^[3] Immunomedicine group, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. ^[4] Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. ^[5] Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.;Trans Chromosomics Inc, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. ^[6] Chromosome Engineering Research Group, The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan.;Homeostatic Regulation, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan. ^[7] Molecular Biosystems Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan. ^[8] Department of Chromosome Biomedical Engineering, Integrated Medical Sciences, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. kazuki@tottori-u.ac.jp.;Department of Chromosome Biomedical Engineering, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. kazuki@tottori-u.ac.jp.;Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. kazuki@tottori-u.ac.jp.;Chromosome Engineering Research Group, The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi, 444-8787, Japan. kazuki@tottori-u.ac.jp. ^[9]

关键词 Bacterial artificial chromosome Chromosome engineering Human leukocyte antigen MHC Mouse model Transgenic mice