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Novel pyrazole derivatives as inhibitors of Leishmania donovani: an integrated approach combining in vitro analysis and mechanistic insights.

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第一作者： Diksha,Kumari

第一单位： Infectious Diseases Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

作者： Diksha,Kumari ^[1] ; Jaspreet,Kour ^[2] ; Anuj,Kumar ^[1] ; Monica,Sangral ^[3] ; Shashank K,Singh ^[4] ; Sanghapal D,Sawant ^[5] ; Kuljit,Singh ^[6]

作者单位： Infectious Diseases Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[1] Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Natural Products and Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India. ^[2] Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India. ^[3] Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Pharmacology Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India. ^[4] Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Natural Products and Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India. Electronic address: sd.sawant@ncl.res.in. ^[5] Infectious Diseases Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: singhkuljit.iiim@csir.res.in. ^[6]

关键词 Cell death Drug discovery FACS analysis Leishmaniasis Pyrazole derivatives Reactive oxygen species (ROS)Scanning electron microscopy