首页> Bioorganic & medicinal chemistry letters> Discovery of the new active ingredient tigolaner, an allosteric modulator of the GABA-gated chloride channel for use as a spot-on ectoparasiticide in animal health.

Discovery of the new active ingredient tigolaner, an allosteric modulator of the GABA-gated chloride channel for use as a spot-on ectoparasiticide in animal health.

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第一作者： Anne,Décor

第一单位： Bayer AG., Research and Development, Crop Science, Alfred Nobel Straße 50, 40789 Monheim-am-Rhein, Germany. Electronic address: anne.decor@bayer.com.

作者： Anne,Décor ^[1] ; Michael,Maue ^[2] ; Hans-Georg,Schwarz ^[2] ; Ulrich,Ebbinghaus-Kintscher ^[2] ; Klaus,Raming ^[2] ; Andreas,Turberg ^[3] ; Norbert,Mencke ^[4] ; Julia Hahn,Neumann ^[2] ; Reiner,Fischer ^[2] ; Werner,Hallenbach ^[2] ; Johannes,Köbberling ^[5] ; Walter,Hübsch ^[5] ; Thomas,Bretschneider ^[2] ; Kerstin,Ilg ^[2] ; Peter,Lösel ^[2] ; Ulrich,Görgens ^[3] ; Niels,Lindner ^[5] ; Katharina,Wölfel ^[2] ; Martin,Adamczewski ^[2]

作者单位： Bayer AG., Research and Development, Crop Science, Alfred Nobel Straße 50, 40789 Monheim-am-Rhein, Germany. Electronic address: anne.decor@bayer.com. ^[1] Bayer AG., Research and Development, Crop Science, Alfred Nobel Straße 50, 40789 Monheim-am-Rhein, Germany. ^[2] Bayer Animal Health GmbH & Elanco Inc. Company, Alfred Nobel Straße 50, 40789 Monheim-am-Rhein, Germany. ^[3] Vetoquinol S.A. 37 rue de la Victoire, 75009, Paris, France. ^[4] Bayer AG., Research and Development, Aprather Weg 18A, 42113 Wuppertal, Germany. ^[5]

关键词 Compounds with ectoparasiticidal activity Inhibitors of GABA-gated chloride channels Lead optimization project leading to tigolaner Pyrazoles combined with a 5-membered ring Tigolaner for tick and flea treatment in cats