首页> Acta pharmacologica Sinica> Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis.

Betaine-homocysteine methyltransferase protects against acetaminophen-induced acute liver failure via BACH1-SCD1-oleic acid axis.

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第一作者： Yu-Ting,Zhang

第一单位： Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.

作者： Yu-Ting,Zhang ^[1] ; Xiao-Ming,Yang ^[2] ; Quan-Shan,Jin ^[1] ; Jia-Yi,Chen ^[1] ; Nan-Bin,Zhu ^[1] ; Yi,Ju ^[1] ; Zi-Yan,Lin ^[1] ; Yang,Zhi ^[3] ; Yi-Nuo,Dong ^[3] ; Chun-Min,Li ^[4] ; Yi-Min,Mao ^[3] ; Xiu-Ling,Zhi ^[1] ; Ming-Yang,Ma ^[5] ; Ya-Li,Xu ^[6] ; Xiao-Bo,Li ^[7]

作者单位： Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. ^[1] NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, 750004, China.;School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China. ^[2] Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine; NHC Key Laboratory of Digestive Diseases; Shanghai Research Center of Fatty Liver Disease, Shanghai, 200001, China. ^[3] Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. ^[4] Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China. nkmmy@163.com. ^[5] Department of Pathology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, 250022, China. skyelia@sina.com. ^[6] Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. xbli@fudan.edu.cn. ^[7]

关键词 acetaminophen-induced liver injury betaine-homocysteine methyltransferase oleic acid stearoyl-coenzyme A desaturase 1

DOI 10.1038/s41401-025-01622-7

PMID 40764413

发布时间 2025-08-09

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