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IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes.

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第一作者: Lei,Bao
第一单位: Department of Dermatology, Rush University Medical Center, Chicago, IL, USA.
作者单位: Department of Dermatology, Rush University Medical Center, Chicago, IL, USA. [1] Department of Dermatology, Rush University Medical Center, Chicago, IL, USA.;Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. [2] Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. [3] Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. [4] Department of Pathology, Rush University Medical Center, Chicago, IL, USA.;Department of Pathology and Laboratory Medicine, Loyola University Stritch School of Medicine, Chicago, IL, USA. [5] Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. [6] Department of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. [7] Department of Dermatology, Rush University Medical Center, Chicago, IL, USA.;Skin Tissue Engineering and Morphology (STEM) Core, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.;Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. [8] Genomics and Microbiome Core Facility, Rush University Medical Center, Chicago, IL, USA. [9] Departments of Internal Medicine and Dermatology, University of Michigan, Ann Arbor, MI, USA. [10] Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA. [11] Research Histology Core, Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA. [12] Translational Science and Experimental Medicine, Early Respiratory & Immunology, AstraZeneca, Gaithersburg, MD, USA. [13] Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.;Department of Dermatology, Allergy, and Venereology, University Clinic Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. [14] Department of Dermatology, Rush University Medical Center, Chicago, IL, USA. kyle_amber@rush.edu. [15]
DOI 10.1038/s41467-025-62495-2
PMID 40769980
发布时间 2025-08-12
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