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Silybin, silychristin and silydianin are potential novel plant-based Pannexin1 channel inhibitors.

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第一作者： Batuhan,Yıldız

第一单位： Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: batuhan.yildiz@vub.be.

作者： Batuhan,Yıldız ^[1] ; Elif İnce,Ergüç ^[2] ; Laureano E,Carpio ^[3] ; Rafael,Gozalbes ^[4] ; Carmen,Ortiz-González ^[5] ; Hilmi,Orhan ^[6] ; Kristiaan,Demeyer ^[7] ; Mathieu,Vinken ^[8] ; Andres,Tabernilla ^[9]

作者单位： Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: batuhan.yildiz@vub.be. ^[1] Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İzmir Katip Çelebi University, İzmir, Türkiye. Electronic address: elif.ince@ikcu.ed.tr. ^[2] ProtoQSAR SL, Nicolás Copérnico, 6, Parque Tecnológico de Valencia, Spain; MolDrug AI Systems SL, Valencia, Spain. Electronic address: lcarpio@protoqsar.com. ^[3] ProtoQSAR SL, Nicolás Copérnico, 6, Parque Tecnológico de Valencia, Spain; MolDrug AI Systems SL, Valencia, Spain. Electronic address: rgozalbes@protoqsar.com. ^[4] ProtoQSAR SL, Nicolás Copérnico, 6, Parque Tecnológico de Valencia, Spain; MolDrug AI Systems SL, Valencia, Spain. Electronic address: cortiz@protoqsar.com. ^[5] Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, İzmir, Türkiye. Electronic address: hilmi.orhan@ege.edu.tr. ^[6] Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: kdemeyer@vub.be. ^[7] Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: mathieu.vinken@vub.be. ^[8] Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: andres.tabernilla.garcia@vub.be. ^[9]

关键词 Pannexin1 Silybum marianum inflammation inhibitor silymarin