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An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial protein import.

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第一作者： Max J,Bachochin

第一单位： Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.

作者： Max J,Bachochin ^[1] ; Kelly L,McGuire ^[1] ; Brian D,Cook ^[1] ; Qiaozhen,Ye ^[2] ; Steve,Silletti ^[1] ; Kevin D,Corbett ^[3] ; Elizabeth A,Komives ^[1] ; Mark A,Herzik ^[1]

作者单位： Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA. ^[1] Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093 USA. ^[2] Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093 USA.;Department of Molecular Biology, University of California San Diego, La Jolla, CA, 92093 USA. ^[3]

DOI 10.1101/2025.07.19.665690

PMID 40777325

发布时间 2026-02-06

基金项目

R35 GM144121/GM/NIGMS NIH HHS/United States R35 GM138206/GM/NIGMS NIH HHS/United States R01 GM129325/GM/NIGMS NIH HHS/United States S10 OD021724/OD/NIH HHS/United States S10 OD016234/OD/NIH HHS/United States T32 GM008326/GM/NIGMS NIH HHS/United States

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An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial protein import.

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An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial protein import.

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