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RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.

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第一作者： Elizabeth A,Mendes

第一单位： Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.;Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

作者： Elizabeth A,Mendes ^[1] ; Aanandi,Munshi ^[2] ; Archana,Singh ^[3] ; Maisie D,Evans ^[4] ; Hsien-Chao,Chou ^[5] ; Yong Yean,Kim ^[5] ; Young,Song ^[5] ; Ara,Jo ^[2] ; Daniel,Lee ^[2] ; Jaida,Ciampi ^[2] ; Audrey,Chambers ^[6] ; Samantha,Weitzel ^[2] ; Michael,Deel ^[2] ; Rex C,Bentley ^[7] ; Javed,Khan ^[5] ; Darrell,Green ^[4] ; Corinne M,Linardic ^[1]

作者单位： Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.;Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC, USA. ^[1] Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. ^[2] Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.;Amity Institute of Biotechnology, Amity Institute of Integrative Sciences and Health, Amity University Haryana, Gurugram, India. ^[3] Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom. ^[4] Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. ^[5] Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.;Department of Biology, University of Evansville, Evansville, IN, USA. ^[6] Department of Pathology, Duke University School of Medicine, Durham, NC, USA. ^[7]

关键词 CADD522 PAX3::FOXO1 RMS RUNX2 Rhabdomyosarcoma

DOI 10.1101/2025.07.21.665972

PMID 40777370

发布时间 2025-09-14

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RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.

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RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.

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