Heterologous COVID-19 vaccine schedule with protein-based prime (NVX-CoV2373) and mRNA boost (BNT162b2) induces strong humoral responses: Results from COV-BOOST trial.
第一作者:
Leila,Janani
第一单位:
Imperial Clinical Trials Unit, Imperial College London, London, UK.
作者:
Leila,Janani [1]
;
Alasdair P S,Munro [2]
;
Annie,Wright [1]
;
Parvinder K,Aley [3]
;
Gavin,Babbage [4]
;
David,Baxter [5]
;
Tanveer,Bawa [6]
;
Sagida,Bibi [7]
;
Marcin,Bula [8]
;
Katrina,Cathie [2]
;
Krishna,Chatterjee [9]
;
Catherine,Cosgrove [10]
;
Yvanne,Enever [11]
;
Eva,Galiza [10]
;
Anna L,Goodman [12]
;
Christopher A,Green [13]
;
Mae,Harris [7]
;
Alexander,Hicks [14]
;
Christine E,Jones [2]
;
Nasir,Kanji [7]
;
Agatha A,van der Klaauw [15]
;
Vincenzo,Libri [16]
;
Martin J,Llewelyn [17]
;
Rebecca,Mansfield [18]
;
Alastair C,McGregor [19]
;
Angela M,Minassian [20]
;
Patrick,Moore [21]
;
Yama F,Mujadidi [22]
;
Hanane Trari,Belhadef [22]
;
Kyra,Holliday [23]
;
Orod,Osanlou [24]
;
Rostam,Osanlou [25]
;
Mihaela,Pacurar [2]
;
Adrian,Palfreeman [26]
;
Karen,Regan [27]
;
Stephen,Saich [4]
;
Dinesh,Saralaya [27]
;
Sunil,Sharma [17]
;
Ray,Sheridan [28]
;
Matthew,Stokes [4]
;
Emma C,Thomson [29]
;
Shirley,Todd [28]
;
Chris,Twelves [23]
;
Daniel,Wright [7]
;
Robert C,Read [2]
;
Sue,Charlton [30]
;
Bassam,Hallis [30]
;
Mary,Ramsay [31]
;
Nick,Andrews [31]
;
Jonathan S,Nguyen-Van-Tam [32]
;
Victoria,Cornelius [1]
;
Teresa,Lambe [7]
;
Paul T,Heath [10]
;
Xinxue,Liu [33]
;
Saul N,Faust [34]
;
COV-BOOST study group
作者单位:
Imperial Clinical Trials Unit, Imperial College London, London, UK.
[1]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
[2]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
[3]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
[4]
Stockport NHS Foundation Trust, Stockport, UK.
[5]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[6]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
[7]
NIHR Liverpool Clinical Research Facility, Liverpool, UK.
[8]
NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[9]
Institute of Infection and Immunity & Vaccine Institute, City St George's, University of London, UK; St George's University Hospitals NHS Foundation Trust, London, UK.
[10]
PHARMExcel, Welwyn Garden City, Hertfordshire, UK.
[11]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
[12]
NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[13]
Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
[14]
Wellcome-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK.
[15]
NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.
[16]
University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
[17]
Dorset Research Hub, Bournemouth, UK.
[18]
Department of Infectious Diseases and Tropical Medicine, London Northwest University Healthcare, London, UK.
[19]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
[20]
The Adam Practice, Poole, UK.
[21]
NIHR Oxford Biomedical Research Centre, Oxford, UK.
[22]
NIHR Leeds Clinical Research Facility, Leeds Teaching Hospitals Trust and University of Leeds, Leeds, UK.
[23]
Public Health Wales, Betsi Cadwaladr University Health Board, Bangor University, Bangor, UK.
[24]
University of Liverpool, Liverpool, UK.
[25]
University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK.
[26]
Bradford Institute for Health Research and Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
[27]
Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.
[28]
Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK; MRC University of Glasgow Centre for Virus Research, Glasgow, UK.
[29]
UK Health Security Agency, Porton Down, UK.
[30]
UK Health Security Agency, Colindale, London, UK.
[31]
Lifespan and Population Health Unit, University of Nottingham School of Medicine, UK.
[32]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK. Electronic address: xinxue.liu@paediatrics.ox.ac.uk.
[33]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. Electronic address: s.faust@soton.ac.uk.
[34]
医学主题词
人类(Humans);免疫接种, 加强(Immunization, Secondary);男(雄)性(Male);女(雌)性(Female);抗体, 病毒(Antibodies, Viral);中年人(Middle Aged);成年人(Adult);免疫, 体液(Immunity, Humoral);免疫接种程序表(Immunization Schedule);抗体, 中和(Antibodies, Neutralizing);老年人(Aged);免疫球蛋白G(Immunoglobulin G);疫苗, 合成(Vaccines, Synthetic)
DOI
10.1016/j.jinf.2025.106576
PMID
40782888
发布时间
2025-09-16
- 浏览1
The Journal of infection
The Journal of infection
106576页
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