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Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis.

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第一作者： Malek,Shatila

第一单位： Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

作者： Malek,Shatila ^[1] ; Kian,Abdul-Baki ^[2] ; Andres,Urias Rivera ^[3] ; Kei,Takigawa ^[3] ; Irene Jeong-Ah,Lee ^[3] ; Andrew,Sullivan ^[4] ; Tanvi,Gupta ^[4] ; Linfeng,Lu ^[3] ; Raakhi,Menon ^[2] ; Ayesha,Khan ^[2] ; Hamza,Salim ^[5] ; Elliot,Baerman ^[3] ; Carolina Colli,Cruz ^[1] ; Cristina,Natha ^[4] ; Varun,Vemulapalli ^[4] ; Garrett,Coleman ^[2] ; Krishnavathana,Varatharajalu ^[1] ; Christopher,Fan ^[6] ; Pablo,Okhuysen ^[7] ; Anthony J,Olszanski ^[8] ; Yan,Zhou ^[9] ; Hao Chi,Zhang ^[1] ; Mehnaz,Shafi ^[1] ; Yinghong,Wang ^[1]

作者单位： Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ^[1] Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, USA. ^[2] Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA. ^[3] Department of Internal Medicine, The University of Texas Health Sciences Center, Houston, Texas, USA. ^[4] Department of Internal Medicine, Memorial Hermann Hospital, Houston, Texas, USA. ^[5] Department of Gastroenterology, Houston Methodist Hospital, Houston, Texas, USA. ^[6] Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ^[7] Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. ^[8] Department of Hospital Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ^[9]

关键词 gastrointestinal infections gut microbiome immune checkpoint inhibitors immune‐mediated colitis intestinal dysbiosis risk factors selective immunosuppressive therapy