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Associations between epilepsy-related polygenic risk and brain morphology in childhood.

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第一作者: Alexander,Ngo
第一单位: Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.;Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1.
作者单位: Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.;Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1. [1] Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.;Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 1Y2. [2] Department of Medical Imaging and Radiation Sciences, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4. [3] Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.;Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23538, Germany.;Centre of Brain, Behavior and Metabolism, University of Lübeck, Lübeck 23562, Germany. [4] Department of Medical Imaging, Nanjing University School of Medicine, Nanjing 211166, China. [5] Centre for Sleep and Cognition, National University of Singapore, Singapore 117549  Singapore.;Centre for Translational Magnetic Resonance, National University of Singapore, Singapore 117549, Singapore.;Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore. [6] Department of Neurology, Duke University, Durham, NC 27710, USA.;Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. [7] Institute of Neuroscience and Medicine (INM-7), Forschungszentrum Jülich, Jülich 52428, Germany. [8] Neuroscience Research Center, University Magna Græcia, Catanzaro 88100, Italy. [9] Institute of Neurology, University Magna Græcia, Catanzaro 88100, Italy. [10] Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro 76230, México. [11] Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.;Walton Centre NHS Foundation Trust, Liverpool L9 7LJ, UK. [12] Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo 13083887, Brazil. [13] Department of Neurology, University of South Carolina School of Medicine, Columbia, SC 29202, USA. [14] Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA. [15] Department of Neurology, University of Medicine Göttingen, Göttingen 37075, Germany. [16] Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC 3004, Australia.;Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia. [17] Departments of Medicine and Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia. [18] Neurophysiology Unit and Epilepsy Centre, Azienda Ospedaliera-Universitaria, Modena 41126, Italy.;Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena 41125, Italy. [19] Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio 70210, Finland.;Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio 70210, Finland. [20] Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran 1439957131, Iran.;Departments of Research Administration and Radiology, Henry Ford Health System, Detroit 48202, USA. [21] Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.;Department of Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.;Chalfont Centre for Epilepsy, Epilepsy Society, Bucks SL9 0RJ, UK. [22] Institute for Molecular Medicine, University of Southern Denmark, Odense s5230, Denmark. [23] Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence 50139, Italy. [24] Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence 50139, Italy.;Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50121, Italy. [25] The Wales Epilepsy Unit, Department of Neurology, University Hospital of Whales, Cardiff CF14 4XW, UK.;Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff CF24 4HQ, UK. [26] Department of Epileptology, University Hospital Bonn, Bonn 53127, Germany.;Department of Neuroradiology, University Hospital Bonn, Bonn 53127, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany.;Center for Medical Data Usability and Translation, University of Bonn, Bonn 53113, Germany. [27] Department of Epileptology, University Hospital Bonn, Bonn 53127, Germany.;Department of Neuroradiology, University Hospital Bonn, Bonn 53127, Germany.;German Center for Neurodegenerative Diseases (DZNE), Bonn 53127, Germany. [28] Department of Neurology, NYU Grossman School of Medicine, New York, NY 10017, USA. [29] Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova 16147, Italy.;IRCCS Instituto Giannina Gaslini, full member of ERN EpiCare, Genova 16147, Italy. [30] Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA. [31] Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093, USA. [32] Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.;Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern 3010, Switzerland. [33] Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital University of Zurich, Zurich 8008, Switzerland.;Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Geneva 1205, Switzerland. [34] Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada K7L 2V7.;Department of Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK. [35] Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. [36] Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA 92093, USA.;Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093, USA. [37] Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada H3A 2B4.;Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada H3A 1A1.;Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 1Y2. [38]
DOI 10.1093/brain/awaf259
PMID 40811581
发布时间 2026-02-07
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Brain : a journal of neurology

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