首页> Nature communications> A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers.

A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers.

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第一作者： Alberto D,Guerra

第一单位： The Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, PA, USA.

作者： Alberto D,Guerra ^[1] ; Smita,Matkar ^[1] ; Christina,Acholla ^[1] ; Colleen,Casey ^[1] ; Grant,Li ^[1] ; Martina,Mazzeschi ^[2] ; Khushbu,Patel ^[1] ; Kateryna,Krytska ^[1] ; Chuan,Chen ^[3] ; Skye,Balyasny ^[1] ; Joshua,Kalna ^[1] ; Paul,Kamitsuka ^[1] ; Mark,Gerelus ^[1] ; Grace,Polkosnik ^[1] ; David,Groff ^[1] ; Apratim,Mukherje ^[4] ; Cynthia,Adams ^[3] ; Gabriela,Witek ^[1] ; Amber K,Hamilton ^[1] ; Daniel,Martinez ^[1] ; Jennifer,Pogoriler ^[1] ; Timothy T,Spear ^[1] ; Yimei,Li ^[1] ; Piotr,Jung ^[1] ; Diego,Alvarado ^[5] ; Mattia,Lauriola ^[6] ; John M,Maris ^[7] ; Adam J,Wolpaw ^[7] ; Kristopher R,Bosse ^[7] ; Dimiter,Dimitrov ^[3] ; Mustafa,Mir ^[8] ; Dontcho V,Jelev ^[3] ; Yael P,Mossé ^[9]

作者单位： The Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, PA, USA. ^[1] IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. ^[2] University of Pittsburgh Medical School, Department of Medicine, Division of Infectious Diseases, Center for Antibody Therapeutics, Pittsburgh, PA, USA. ^[3] University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia, PA, USA. ^[4] Celldex Therapeutics, Antibody Therapeutics Department, Hampton, NJ, USA. ^[5] IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.;University of Bologna, Department of Medical and Surgical Sciences, Bologna, Italy. ^[6] The Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, PA, USA.;Perelman School of Medicine at the University of Pennsylvania, Department of Pediatrics, Philadelphia, PA, USA. ^[7] The Children's Hospital of Philadelphia, Center for Computational and Genomic Medicine, Philadelphia, PA, USA. ^[8] The Children's Hospital of Philadelphia, Division of Oncology and Center for Childhood Cancer Research, Philadelphia, PA, USA. mosse@chop.edu.;Perelman School of Medicine at the University of Pennsylvania, Department of Pediatrics, Philadelphia, PA, USA. mosse@chop.edu. ^[9]