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Combination nitazoxanide and auranofin treatment has synergistic anticancer activity in anaplastic thyroid cancer through enhanced activation of oxidative stress that leads to apoptosis.

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第一作者： Chandrayee,Ghosh

第一单位： Department of Surgery, Stanford University, Stanford, CA, USA. Electronic address: cghosh@stanford.edu.

作者： Chandrayee,Ghosh ^[1] ; Tejinder Pal,Khaket ^[2] ; Viswanath,Gunda ^[2] ; Zhongyue,Yang ^[2] ; Jiangnan,Hu ^[2] ; Eden Demissie,Alamaw ^[3] ; Lisa,Zhang ^[4] ; Ya-Qin,Zhang ^[5] ; Min,Shen ^[5] ; Yasmine,Tabdili ^[6] ; Myriem,Boufraqech ^[7] ; Rodas,Kassu ^[2] ; Electron,Kebebew ^[8]

作者单位： Department of Surgery, Stanford University, Stanford, CA, USA. Electronic address: cghosh@stanford.edu. ^[1] Department of Surgery, Stanford University, Stanford, CA, USA. ^[2] Department of Comparative Medicine, Veterinary Service Center, Stanford University, Stanford, CA, USA. ^[3] Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. ^[4] National Center for Advancing Translational Sciences, National Institute of Health, Bethesda, MD, USA. ^[5] University of Arizona, College of Medicine, Tucson, AZ, USA. ^[6] Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA. ^[7] Department of Surgery, Stanford University, Stanford, CA, USA. Electronic address: kebebew@stanford.edu. ^[8]

关键词 Anaplastic thyroid cancer Auranofin Cell death Combination therapy Nitazoxanide Synergism

DOI 10.1016/j.canlet.2025.217990

PMID 40834985

发布时间 2025-12-04

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