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Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy.

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第一作者: Erez N,Baruch
第一单位: Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
作者单位: Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [1] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [2] Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [3] Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [4] Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.;Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. [5] Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. [6] The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA. [7] Department of Head and Neck Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [8] Department of Melanoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [9] James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [10] Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, London, UK.;Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. [11] Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Massachusetts Institute of Technology, Cambridge, MA, USA. [12] Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [13] Division of Cancer Medicine, Hematology and Oncology Fellowship program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [14] Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [15] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [16] Department of Biology and Biochemistry, University of Houston Sequencing and Gene Editing Core, University of Houston, Houston, TX, USA. [17] Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [18] Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. [19] Department of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jingwang@mdanderson.org. [20] Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [21] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [22] Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [23] Translational Research Center, New York University College of Dentistry, New York, NY, USA.;Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA. [24] Center for Systems Biology, Krantz Family Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. [25] Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA. [26] Department of Periodontics and Oral Medicine, The University of Michigan, Ann Arbor, MI, USA.;Department of Pathology, The University of Michigan, Ann Arbor, MI, USA. [27] Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. [28] Department of Hematopoietic Biology & Malignancies, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [29] Department of Pain Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [30] Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Kenneth.Tsai@moffitt.org.;Department of Tumor Microenvironment & Metastasis, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA. Kenneth.Tsai@moffitt.org. [31] James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [32] Platform for Innovative Microbiome and Translational Research, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.;Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [33] Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. sebas.talbot@gmail.com.;Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada. sebas.talbot@gmail.com. [34] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Ndgross@mdanderson.org. [35] Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com.;Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com.;UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Moranamit@gmail.com.;Cancer Neuroscience Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Moranamit@gmail.com. [36]
DOI 10.1038/s41586-025-09370-8
PMID 40836096
发布时间 2026-04-22
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