首页> Toxicology in vitro : an international journal published in association with BIBRA> Cytotoxic and immunotoxic profile of HgCl<sub>2</sub> involves alterations in purinergic signaling through the P2X7/NLRP3/CASP-1/IL-1β pathway: An in vitro study using human blood immune cells.

Cytotoxic and immunotoxic profile of HgCl<sub>2</sub> involves alterations in purinergic signaling through the P2X7/NLRP3/CASP-1/IL-1β pathway: An in vitro study using human blood immune cells.

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第一作者： Mairin,Schott

第一单位： Postgraduate Program in Biological Sciences, Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: mairinschottms@gmail.com.

作者： Mairin,Schott ^[1] ; Charles Elias,Assmann ^[2] ; Bianca Vedoin Copês,Rambo ^[2] ; Marcylene Vieira,da Silveira ^[2] ; Milagros Fanny Vera,Castro ^[2] ; Vitor Bastianello,Mostardeiro ^[2] ; Adriel Antônio,Schirmann ^[2] ; Robson Lourenço,da Silva Santos ^[2] ; Pâmela,de Almeida Milioni ^[2] ; Ana Barbosa,Viana ^[3] ; Valderi Luiz,Dressler ^[3] ; Daniel Lázaro Gallindo,Borges ^[4] ; Nilda Berenice,de Vargas Barbosa ^[2] ; Vera Maria Melchiors,Morsch ^[2] ; Michael,Aschner ^[5] ; João Batista Teixeira,da Rocha ^[6] ; Maria Rosa Chitolina,Schetinger ^[2]

作者单位： Postgraduate Program in Biological Sciences, Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address: mairinschottms@gmail.com. ^[1] Postgraduate Program in Biological Sciences, Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil. ^[2] Department of Chemistry, Laboratory of Microanalyses and Portability, Federal University of Santa Maria, Santa Maria, RS, Brazil. ^[3] Chemistry Department, Federal University of Santa Catarina, Florianópolis, SC, Brazil. ^[4] Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA. ^[5] Postgraduate Program in Biological Sciences, Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil; Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. ^[6]

关键词 Cytotoxicity Gene expression Inflammation Mercuric chloride Oxidative stress Pyroptosis