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Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett's esophagus.

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第一作者： Ceylan,Tanes

第一单位： Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

作者： Ceylan,Tanes ^[1] ; Yun,Li ^[2] ; Gary W,Falk ^[3] ; Gregory G,Ginsberg ^[3] ; Kenneth K,Wang ^[4] ; Prasad G,Iyer ^[5] ; Charles J,Lightdale ^[6] ; Armando,Del Portillo ^[7] ; Stephen M,Lagana ^[7] ; Timothy C,Wang ^[8] ; Anil K,Rustgi ^[8] ; Michael,Quante ^[9] ; Zhezhen,Jin ^[10] ; Gary D,Wu ^[3] ; Elliot S,Friedman ^[3] ; Kyle,Bittinger ^[1] ; Hongzhe,Li ^[2] ; Julian A,Abrams ^[8]

作者单位： Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[1] Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. ^[2] Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. ^[3] Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. ^[4] Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA. ^[5] Division of Digestive & Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.;Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. ^[6] Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. ^[7] Division of Digestive & Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.;Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.;Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY, USA. ^[8] Department of Medicine II, University of Freiburg, Freiburg, Germany. ^[9] Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA. ^[10]

关键词 Barrett’s esophagus bile acids esophageal adenocarcinoma microbiome