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Cyclin-dependent kinase 1 (CDK1) in cancers: from upstream regulation to downstream substrates and therapeutic inhibitors.

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第一作者： Ji,Chen

第一单位： Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Southwest Bio-Resources R&D Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China; Department of Medical Oncology, The Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, China.

作者： Ji,Chen ^[1] ; Xiaobo,Wang ^[2] ; Jia,Wang ^[3] ; Xiaoyun,Nie ^[3] ; Jinqi,Ji ^[3] ; Xuesha,Liu ^[4] ; Haoran,Tian ^[3] ; Chenghua,Li ^[5]

作者单位： Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Southwest Bio-Resources R&D Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China; Department of Medical Oncology, The Seventh People's Hospital of Chengdu, Chengdu, 610041, Sichuan, China. ^[1] Innovative Institute of Chinese Medicine and Pharmacy/Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China. ^[2] Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Southwest Bio-Resources R&D Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China. ^[3] College of Life Sciences, China West Normal University, Nanchong, 637009, Sichuan, China. ^[4] Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Southwest Bio-Resources R&D Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China. Electronic address: lichenghua@scu.edu.cn. ^[5]

关键词 Cancer progression Cyclin-dependent kinase 1 (CDK1)Inhibitor Phosphorylation Tumorigenesis

医学主题词人类(Humans);肿瘤(Neoplasms);CDC2蛋白激酶(CDC2 Protein Kinase);蛋白激酶抑制剂(Protein Kinase Inhibitors);抗肿瘤药(Antineoplastic Agents);细胞增殖(Cell Proliferation);动物(Animals)

DOI 10.1016/j.ejmech.2025.118090

PMID 40865142

发布时间 2025-09-10

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