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Bispecific antibody engineered from two non-protective antibodies confers full protection against anthrax toxin through inhibition of PA83 cleavage.

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第一作者： Zhengshan,Chen

第一单位： Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China.

作者： Zhengshan,Chen ^[1] ; Guanying,Zhang ^[1] ; Jin,Han ^[1] ; Zheng,Zhu ^[1] ; Meirong,Wang ^[1] ; Ting,Fang ^[1] ; Zeya,Li ^[1] ; Yunzhu,Dong ^[1] ; Jianmin,Li ^[1] ; Changming,Yu ^[1] ; Xiangyang,Chi ^[1]

作者单位： Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China. ^[1]

关键词 Bacillus anthracis bispecific antibody neutralizing mechanism non-protective antibody protective antigen

医学主题词细菌毒素类(Bacterial Toxins);抗原, 细菌(Antigens, Bacterial);抗体, 双特异性(Antibodies, Bispecific);动物(Animals);炭疽(Anthrax);抗体, 细菌(Antibodies, Bacterial);抗体, 单克隆(Antibodies, Monoclonal);小鼠(Mice);炭疽芽孢杆菌(Bacillus anthracis);抗体, 中和(Antibodies, Neutralizing);人类(Humans);小鼠, 近交BALB C(Mice, Inbred BALB C);女(雌)性(Female)

DOI 10.1128/spectrum.00588-25

PMID 40879394

发布时间 2025-10-09

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Bispecific antibody engineered from two non-protective antibodies confers full protection against anthrax toxin through inhibition of PA83 cleavage.

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Bispecific antibody engineered from two non-protective antibodies confers full protection against anthrax toxin through inhibition of PA83 cleavage.

Microbiology spectrum

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