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New players from the old chalcone scaffold: Synthesis, identification, and characterization of new potent ABCG2 inhibitors.

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第一作者： Bruna Estelita,Ruginsk

第一单位： Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil; Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil.

作者： Bruna Estelita,Ruginsk ^[1] ; Ingrid Fatima,Zattoni ^[2] ; Arthur Henrique,Gomes De Oliveira ^[3] ; Isadora da Silva,Zanzarini ^[4] ; Fabiane Gomes,de Moraes Rego ^[5] ; Geraldo,Picheth ^[5] ; Antti,Poso ^[6] ; Thales,Kronenberger ^[7] ; Katalin,Goda ^[8] ; Vivian Rotuno,Moure ^[4] ; Ahcène,Boumendjel ^[9] ; Glaucio,Valdameri ^[10]

作者单位： Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil; Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil. ^[1] Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil; Univ. Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France. ^[2] Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil; Interfaculty Institute of Microbiology and Infection Medicine (IMIT), DZIF Tübingen Partner Site. University Hospital Tübingen, Tübingen, Germany. ^[3] Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil. ^[4] Graduate Program in Pharmaceutical Sciences, Federal University of Parana, Curitiba, 80210-170, PR, Brazil. ^[5] School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211, Kuopio, Finland. ^[6] Interfaculty Institute of Microbiology and Infection Medicine (IMIT), DZIF Tübingen Partner Site. University Hospital Tübingen, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211, Kuopio, Finland. ^[7] Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Egyetem Tér 1, Debrecen, H-4032, Hungary. ^[8] Univ. Grenoble Alpes, INSERM, LRB, 38000, Grenoble, France. Electronic address: ahcene.boumendjel@univ-grenoble-alpes.fr. ^[9] Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, 80210-170, PR, Brazil; Graduate Program in Cell and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil. Electronic address: gvaldameri@ufpr.br. ^[10]

关键词 ABCG2 Cancer Chalcones Inhibitors Multidrug resistance (MDR)