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Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8<sup>+</sup> T cells.

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第一作者： Irem,Ozel

第一单位： Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.

作者： Irem,Ozel ^[1] ; Guanyu,Sha ^[1] ; Agnieszka,Będzińska ^[2] ; Ekaterina,Pylaeva ^[1] ; Yuliia,Naumova ^[1] ; Ilona,Thiel ^[1] ; Joanna,Antczak ^[1] ; Anthony,Squire ^[3] ; Matthias,Gunzer ^[3] ; Gennadiy,Zelinskyy ^[4] ; Cornelius,Kürten ^[1] ; Stephan,Lang ^[5] ; Carlos,Silvestre-Roig ^[6] ; Marcin,Kortylewski ^[7] ; Zvi,Granot ^[8] ; Jadwiga,Jablonska ^[9]

作者单位： Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany. ^[1] Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, 44101, Poland. ^[2] Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, 45141, Germany. ^[3] Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany. ^[4] Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany.;German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany. ^[5] Institute of Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, 48149, Germany. ^[6] Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.;Center for Gene Therapy, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA. ^[7] Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Faculty of Medicine, Hebrew University, Jerusalem, 91120, Israel. ^[8] Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Essen, Essen, University of Duisburg-Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de.;German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, 45147, Germany. jadwiga.jablonska@uk-essen.de. ^[9]

医学主题词动物(Animals);STAT3转录因子(STAT3 Transcription Factor);小鼠(Mice);中性白细胞(Neutrophils);人类(Humans);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);肿瘤(Neoplasms);信号传导(Signal Transduction);疾病恶化(Disease Progression);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1038/s41392-025-02363-z

PMID 40885734

发布时间 2025-09-03

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Signal transduction and targeted therapy

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Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8<sup>+</sup> T cells.

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Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8<sup>+</sup> T cells.

Signal transduction and targeted therapy

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