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Targeting the NLRP3 inflammasome: Pharmacological mechanisms for the treatment of dry eye disease.

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第一作者： Jinjin,Gong

第一单位： School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China; Department of Ophthalmology, Jinan Second People's Hospital, Jinan, 250000, China.

作者： Jinjin,Gong ^[1] ; Tingting,Du ^[2] ; Gang,Ding ^[2] ; Tingting,Gao ^[1] ; Zhongkai,Hao ^[2] ; Mengyao,Li ^[3] ; Zhiyuan,Wang ^[1] ; Yuchun,Li ^[4] ; Xu,Wang ^[5] ; Chenming,Zhang ^[6]

作者单位： School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China; Department of Ophthalmology, Jinan Second People's Hospital, Jinan, 250000, China. ^[1] Department of Ophthalmology, Jinan Second People's Hospital, Jinan, 250000, China. ^[2] Department of Ophthalmology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250014, China. ^[3] Wuxi No.2 Chinese Medicine Hospital, Wuxi, 214026, China. ^[4] School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China; Department of Ophthalmology, Jinan Second People's Hospital, Jinan, 250000, China. Electronic address: wangxuzou@126.com. ^[5] School of Clinical Medicine, Shandong Second Medical University, Weifang, 261000, Shandong, China; Department of Ophthalmology, Jinan Second People's Hospital, Jinan, 250000, China. Electronic address: chenming-zhang@163.com. ^[6]

关键词 Dry eye disease Inflammation NLRP3 inflammasome Pharmacological mechanisms Research advances

医学主题词人类(Humans);干眼综合征(Dry Eye Syndromes);炎性体(Inflammasomes);动物(Animals);消炎药(Anti-Inflammatory Agents);分子靶向治疗(Molecular Targeted Therapy)

DOI 10.1016/j.ejphar.2025.178104

PMID 40886875

发布时间 2025-12-10

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