首页> Frontiers in pharmacology> Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress.

Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress.

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第一作者： Zhifeng,Chen

第一单位： Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Fujian Institute of Otolaryngology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

作者： Zhifeng,Chen ^[1] ; Ting,Xie ^[2] ; Chenyu,Chen ^[3] ; Tingting,Lin ^[4] ; Xiaobo,Wu ^[5] ; Yuqing,Chen ^[5] ; Yanchun,Lin ^[5] ; Xiaoyang,Luo ^[5] ; Chaojun,Zeng ^[6] ; Chang,Lin ^[1]

作者单位： Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Fujian Institute of Otolaryngology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. ^[1] Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. ^[2] Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.;NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai, China. ^[3] University of Science and Technology of China, Hefei, China. ^[4] Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, China. ^[5] Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou, China.;Department of Otolaryngology, Affiliated Hospital of Putian University, Putian, China.;Putian Institute of Otolaryngology, Affiliated Hospital of Putian University, Putian, China. ^[6]

关键词 apoptosis cisplatin ferroptosis ototoxicity oxidative stress sarsasapogenin

DOI 10.3389/fphar.2025.1641174

PMID 40894222

发布时间 2025-09-15

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