首页> Current research in pharmacology and drug discovery> The simultaneous activation of μ- and δ-opioid receptors by (-)-2<i>S</i>-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

The simultaneous activation of μ- and δ-opioid receptors by (-)-2<i>S</i>-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

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第一作者： A,Fidilio

第一单位： Department of Drug and Health Sciences, University of Catania, Catania, Italy.;Oasi Research Institute - IRCCS, Troina, Italy.

作者： A,Fidilio ^[1] ; M,Grasso ^[2] ; S,Spoto ^[3] ; S,Varrasi ^[4] ; M,Al-Khrasani ^[5] ; F,Caraci ^[1] ; C,Parenti ^[4] ; L,Pasquinucci ^[4]

作者单位： Department of Drug and Health Sciences, University of Catania, Catania, Italy.;Oasi Research Institute - IRCCS, Troina, Italy. ^[1] Oasi Research Institute - IRCCS, Troina, Italy. ^[2] Department of Drug and Health Sciences, University of Catania, Catania, Italy.;A.O.U. Policlinico "G. Rodolico - San Marco", Catania, Italy. ^[3] Department of Drug and Health Sciences, University of Catania, Catania, Italy. ^[4] Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, H-1089, Budapest, Hungary. ^[5]

关键词 Allodynia Biased MOR/DOR agonist Neuropathic pain Opioid receptors TGF-β1

DOI 10.1016/j.crphar.2025.100229

PMID 40895022

发布时间 2025-09-15

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The simultaneous activation of μ- and δ-opioid receptors by (-)-2<i>S</i>-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

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The simultaneous activation of μ- and δ-opioid receptors by (-)-2<i>S</i>-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model.

Current research in pharmacology and drug discovery

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Current research in pharmacology and drug discovery

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