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Establishing scientific confidence in a two-chamber co-culture system to evaluate androgenic response in the presence of hepatic metabolism.

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第一作者： Tessa C A,van Tongeren

第一单位： Division of Toxicology, Wageningen University and Research, Wageningen 6700 EA, the Netherlands. Electronic address: tcavantongeren@gmail.com.

作者： Tessa C A,van Tongeren ^[1] ; Susan J,Hall ^[2] ; Samantha J,Madnick ^[3] ; Blanche C,Ip ^[3] ; Paul L,Carmichael ^[4] ; Hequn,Li ^[4] ; Wei,Chen ^[5] ; Lori A,Breitweiser ^[5] ; Heather E,Pence ^[5] ; David M,Ames ^[5] ; Andrew J,Bowling ^[5] ; Kamin J,Johnson ^[5] ; Richard,Cubberley ^[4] ; Bruce,Sherf ^[6] ; Jeffrey R,Morgan ^[3] ; Kim,Boekelheide ^[7]

作者单位： Division of Toxicology, Wageningen University and Research, Wageningen 6700 EA, the Netherlands. Electronic address: tcavantongeren@gmail.com. ^[1] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA. ^[2] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA; Center for Alternatives to Animals in Testing, Brown University, Providence, RI, USA. ^[3] Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedfordshire MK44 1LQ, UK. ^[4] Corteva, Inc., Indianapolis, IN, USA. ^[5] INDIGO Biosciences, Inc., State Collage, PA, USA. ^[6] Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA; Center for Alternatives to Animals in Testing, Brown University, Providence, RI, USA. Electronic address: kim_Boekelheide@brown.edu. ^[7]

关键词 3D HepaRG microtissues AR-CALUX AR-INDIGO Toxicity testing in vitro testing

DOI 10.1016/j.toxlet.2025.08.014

PMID 40902835

发布时间 2025-09-15

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