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ROS-responsive resiquimod prodrug nanoparticles for macrophage reprogramming and enhanced immune checkpoint inhibitor therapy in bladder cancer.

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第一作者： Rui,Geng

第一单位： Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.

作者： Rui,Geng ^[1] ; Haojie,Shang ^[2] ; Zhiqiang,Chen ^[3] ; Kun,Tang ^[4] ; Yijing,Liu ^[5] ; Jintao,Zhu ^[1]

作者单位： Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China. ^[1] Department of Urology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, 430030, China; Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ^[2] Department of Urology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, 430030, China. ^[3] Department of Urology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, 430030, China; Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, 518057, China. Electronic address: tangsk1990@163.com. ^[4] Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Hubei Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China; Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, 518057, China. Electronic address: yijingliu@hust.edu.cn. ^[5]

关键词 Bladder cancer Immune checkpoint inhibitor therapy Macrophage repolarization ROS-Responsive Resiquimod prodrug