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Development and Evaluation of Dual Microneedle Array Patch for Sequential Intradermal Delivery of Adjuvant and Antigen.

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第一作者： Ye-Lim,Lee

第一单位： Department of BioNano Technology, Gachon BioNano Research Institute, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea.

作者： Ye-Lim,Lee ^[1] ; Hye-Ran,Cha ^[2] ; Da-Eun,Lee ^[1] ; Minwoo,Ryu ^[1] ; Hyeon Woo,Chung ^[2] ; Sunghoon,Park ^[2] ; Jung-Ah,Choi ^[3] ; Seung-Ki,Baek ^[4] ; Jae Myun,Lee ^[5] ; Jung-Hwan,Park ^[6]

作者单位： Department of BioNano Technology, Gachon BioNano Research Institute, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea. ^[1] Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. ^[2] Science Unit, International Vaccine Institute, Gwanak-Gu, Seoul, 08826, Republic of Korea. ^[3] QuadMedicine R&D Centre, Quad Medicine, Inc., Seongnam, Gyeonggi-Do, 13209, Republic of Korea. ^[4] Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. jaemyun@yuhs.ac. ^[5] Department of BioNano Technology, Gachon BioNano Research Institute, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea. pa90201@gachon.ac.kr. ^[6]

关键词 Flexible adjuvant dose Independent antigen-adjuvant formulation Selective adjuvant administration Sequential antigen-adjuvant delivery Vaccine microneedle