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Targeted degradation of hexokinase 2 by a novel engineered bispecific chimeric liposome-based Nano-PROTACs for enhancing tumor chemotherapy.

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第一作者： Linlin,Gong

第一单位： Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Guangdong, 518057, China.

作者： Linlin,Gong ^[1] ; Shasha,Li ^[1] ; Jiahui,Sun ^[1] ; Runjie,Liu ^[1] ; Jianling,Wang ^[2] ; Simeng,Wang ^[2] ; Yuelei,Zhao ^[2] ; Li,Yan ^[3] ; Meiju,Ji ^[2] ; Dan,Yang ^[4] ; Peng,Hou ^[5] ; Dechun,Liu ^[6]

作者单位： Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Guangdong, 518057, China. ^[1] Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. ^[2] Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China. ^[3] Department of Pharmaceutical Sciences, School of Biological and Pharmaceutical Sciences, Shaanxi University of Science and Technology, Weiyang University Park, Xi'an, 710021, China. Electronic address: ydan326@163.com. ^[4] Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address: phou@xjtu.edu.cn. ^[5] Institute of Medical Research, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Guangdong, 518057, China. Electronic address: dechun.liu@nwpu.edu.cn. ^[6]

关键词 Aerobic glycolysis Liposome Targeted protein degradation Tumor chemotherapy Ubiquitin proteasome system