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Engineering ferroptosis radiosensitizer for SPARC-targeted degradation: A strategy to reverse radioresistant non-small cell lung cancer.

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第一作者： Reyida,Aishajiang

第一单位： State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130062, China.

作者： Reyida,Aishajiang ^[1] ; Yuan,Liang ^[2] ; Pengye,Du ^[2] ; Xiqian,Zhuo ^[1] ; Shuyu,Liu ^[2] ; Yi,Wei ^[3] ; Tiejun,Wang ^[4] ; Pengpeng,Lei ^[5] ; Duo,Yu ^[6] ; Hongjie,Zhang ^[7]

作者单位： State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130062, China. ^[1] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China. ^[2] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. ^[3] Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130062, China. ^[4] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. Electronic address: leipp@ciac.ac.cn. ^[5] Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130062, China. Electronic address: yuduo@jlu.edu.cn. ^[6] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address: hongjie@ciac.ac.cn. ^[7]

关键词 Ferroptosis Radiation therapy Radioresistant NSCLC Radiosensitizer SPARC