首页> Developmental biology> CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development.

CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development.

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第一作者： Emanuele,Pignatti

第一单位： Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.

作者： Emanuele,Pignatti ^[1] ; Lijie,Jiang ^[2] ; Manasvi S,Shah ^[1] ; Anish,Karpurapu ^[3] ; Ji,Miao ^[1] ; Yangyang,Liu ^[2] ; Mesut,Berber ^[1] ; Roshini,Kalagara ^[3] ; Aisling E,Butler ^[2] ; David G,Skalnik ^[4] ; Vicki,Rosen ^[5] ; David T,Breault ^[6] ; Diana L,Carlone ^[7]

作者单位： Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA. ^[1] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA. ^[2] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA; Harvard Stem Cell Institute, 7 Divinity Ave, Cambridge, MA, 02138, USA. ^[3] Department of Biology, IUPUI School of Science, Indianapolis, IN, 46202, USA. ^[4] Harvard Stem Cell Institute, 7 Divinity Ave, Cambridge, MA, 02138, USA; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA. ^[5] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA; Harvard Stem Cell Institute, 7 Divinity Ave, Cambridge, MA, 02138, USA. ^[6] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA; Harvard Stem Cell Institute, 7 Divinity Ave, Cambridge, MA, 02138, USA. Electronic address: diana.carlone@childrens.harvard.edu. ^[7]

关键词 BMP signaling Chondrogenesis Differentiation Epigenetics

医学主题词动物(Animals);信号传导(Signal Transduction);小鼠(Mice);骨形态发生蛋白质类(Bone Morphogenetic Proteins);细胞分化(Cell Differentiation);软骨发生(Chondrogenesis);猬蛋白质类(Hedgehog Proteins);四肢(Extremities);间质干细胞(Mesenchymal Stem Cells);基因表达调控, 发育期(Gene Expression Regulation, Developmental);Smad1蛋白质(Smad1 Protein);骨生成(Osteogenesis)

DOI 10.1016/j.ydbio.2025.09.004

PMID 40915528

发布时间 2026-03-25

基金项目

P30 AR066261/AR/NIAMS NIH HHS/United States P30 AR075042/AR/NIAMS NIH HHS/United States R01 AR074982/AR/NIAMS NIH HHS/United States R03 AG054723/AG/NIA NIH HHS/United States

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准确一般字义偏差语意偏离译文作用小提交