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Lactate Metabolic Reprogramming Mediated by CircRNA-LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer.

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第一作者： Hao,Shen

第一单位： Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.;National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Hangzhou, 310016, China.;Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.

作者： Hao,Shen ^[1] ; Boqiang,Liu ^[1] ; Jing,He ^[1] ; Weijun,Zhao ^[1] ; Weiqi,Li ^[2] ; Lingfeng,Ma ^[3] ; Lidan,Hou ^[1] ; Yi,Wang ^[1] ; Chenqi,Jin ^[2] ; Yushun,Chang ^[1] ; Jie,Lin ^[1] ; Jia,Zhao ^[4] ; Binghan,Jin ^[5] ; Yuanshi,Tian ^[6] ; Xiujun,Cai ^[1] ; Liang,Shi ^[1] ; Yifan,Wang ^[1]

作者单位： Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.;National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Hangzhou, 310016, China.;Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. ^[1] Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. ^[2] Department of Oncology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. ^[3] Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Zhejiang University, Hangzhou, 310016, China. ^[4] Department of Endocrinology, The Children's Hospital, National Clinical Research Center for Child Health, School of Medicine, Zhejiang University, Hangzhou, 310053, China. ^[5] Department of Diagnostic Ultrasound & Echocardiography, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China. ^[6]

关键词 circular RNA immune evasion lactate metabolism liver cancer natural killer cell protein degradation