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Reduction of systemic inflammation by elexacaftor/tezacaftor/ivacaftor correlates with lung function improvement in cystic fibrosis.

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第一作者: Olga,Halle
第一单位: Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany.;O. Halle and S.Y. Graeber contributed equally as first authors.
作者单位: Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany.;O. Halle and S.Y. Graeber contributed equally as first authors. [1] Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.;German Center for Lung Research (DZL), associated partner site Berlin, Berlin, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.;Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.;O. Halle and S.Y. Graeber contributed equally as first authors. [2] Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany. [3] Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. [4] German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany.;Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany. [5] Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.;German Center for Lung Research (DZL), associated partner site Berlin, Berlin, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.;Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany. [6] Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.;German Center for Lung Research (DZL), associated partner site Berlin, Berlin, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany. [7] Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.;Department of Translational Pulmonology, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany. [8] Department of Translational Pulmonology, Heidelberg University Hospital, Heidelberg, Germany. [9] Department of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany.;Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. [10] Dr von Hauner Children's Hospital, Ludwig Maximilians University, Comprehensive Pneumology Center - Munich (CPC-M), Member of German Center for Lung Research (DZL), German Center for Child and Adolescent Health (DZKJ), LMU Munich, Munich, Germany. [11] Department of Pediatrics, Section of Pediatric Pneumology, University of Lübeck, Lübeck, Germany.;Airway Research Center North (ARCN), Germany, German Center for Lung Research (DZL), Lübeck, Germany. [12] Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany. [13] CF Centre Cologne, Childrens Hospital, Faculty of Medicine and University of Cologne, Cologne, Germany.;Centre for Rare Diseases, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. [14] Department of Pneumology and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany. [15] Department of Pediatrics, Section of Pediatric Pneumology, University of Lübeck, Lübeck, Germany.;Airway Research Center North (ARCN), Germany, German Center for Lung Research (DZL), Lübeck, Germany.;Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany. [16] Department of Medicine 1, Research Division Infection Biology, Medical University of Vienna, Vienna, Austria. [17] Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany.;Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany. [18] Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.;German Center for Lung Research (DZL), associated partner site Berlin, Berlin, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.;Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.;M.A. Mall and A-M. Dittrich contributed equally as senior authors. [19] Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany dittrich.anna-maria@mh-hannover.de.;German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover, Germany.;Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany.;M.A. Mall and A-M. Dittrich contributed equally as senior authors. [20]
DOI 10.1183/13993003.00150-2025
PMID 40967763
发布时间 2025-12-26
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The European respiratory journal

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