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The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.

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第一作者： Akimasa,Hayashi

第一单位： David M. Rubenstein Center for Pancreatic Cancer Research, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Department of Pathology, Kyorin University School of Medicine, Mitaka, Japan.

作者： Akimasa,Hayashi ^[1] ; Yu-Jui,Ho ^[2] ; Alvin P,Makohon-Moore ^[3] ; Amanda,Zucker ^[4] ; Jungeui,Hong ^[4] ; Shigeaki,Umeda ^[4] ; Elias-Ramzey,Karnoub ^[4] ; Jinlong,Huang ^[4] ; Priscilla,Baez ^[4] ; Rajya,Kappagantula ^[4] ; Jerry P,Melchor ^[4] ; Wungki,Park ^[5] ; Eileen M,O'Reilly ^[5] ; Nicholas D,Socci ^[6] ; Shinya,Oki ^[7] ; Christine A,Iacobuzio-Donahue ^[4]

作者单位： David M. Rubenstein Center for Pancreatic Cancer Research, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Department of Pathology, Kyorin University School of Medicine, Mitaka, Japan. ^[1] Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York. ^[2] Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey.;Georgetown University Lombardi Comprehensive Cancer Center, Washington, District of Columbia. ^[3] David M. Rubenstein Center for Pancreatic Cancer Research, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York. ^[4] David M. Rubenstein Center for Pancreatic Cancer Research, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York.;Gastrointestinal Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.;Weill Cornell Department of Medicine, Weill Cornell Medicine, New York, New York. ^[5] Bioinformatics Core, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York. ^[6] Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. ^[7]

医学主题词胰腺肿瘤(Pancreatic Neoplasms);人类(Humans);增强子元件, 遗传学(Enhancer Elements, Genetic);突变(Mutation);动物(Animals);小鼠(Mice);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);启动区, 遗传(Promoter Regions, Genetic)

DOI 10.1158/2767-9764.CRC-24-0167

PMID 40971319

发布时间 2026-03-07

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Cancer research communications

2025年5卷10期

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Cancer research communications

2025年5卷10期

1839-1851页

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The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.

Cancer research communications

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The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.

Cancer research communications

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Cancer research communications

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