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Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies.

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第一作者： Sara,Salzano

第一单位： Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy.

作者： Sara,Salzano ^[1] ; Chiara,Bertasini ^[1] ; Shima,Tavakolian Haghighi ^[1] ; Johan,Lundkvist ^[2] ; Lars U,Wahlberg ^[3] ; Cristiano,Chiamulera ^[1] ; Gaetano Na,Vattemi ^[4] ; Fabrizio,Gardoni ^[5] ; Giovanna,Paolone ^[6]

作者单位： Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy. ^[1] Sinfonia Biotherapeutics AB, Huddinge, Sweden; Department of NVS, Karolinska Institute, Solna, Sweden. ^[2] Sinfonia Biotherapeutics AB, Huddinge, Sweden; Gloriana Therapeutics Inc, Warren, RI, USA. ^[3] Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Neurology, University of Verona, Verona, Italy. ^[4] Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy. ^[5] Department of Diagnostics and Public Health, Section of Pharmacology, University of Verona, Verona, Italy. Electronic address: giovanna.paolone@univr.it. ^[6]

关键词 GRN-FTD Gene mutations PGRN Preclinical models TDP-43 aggregates Therapeutic treatments

医学主题词人类(Humans);额颞叶痴呆(Frontotemporal Dementia);动物(Animals);突变(Mutation);疾病模型, 动物(Disease Models, Animal)

DOI 10.1016/j.phrs.2025.107957

PMID 40972833

发布时间 2026-05-28

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