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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD.

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第一作者： Tianshi,Feng

第一单位： Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

作者： Tianshi,Feng ^[1] ; Qin,Luo ^[2] ; Yanlin,Liu ^[1] ; Zeyu,Jin ^[1] ; David,Skwarchuk ^[1] ; Rumi,Lee ^[3] ; Miso,Nam ^[2] ; John M,Asara ^[4] ; Daya R,Adye ^[1] ; Philip L,Lorenzi ^[5] ; Lin,Tan ^[5] ; Guangsheng,Pei ^[6] ; Zhongming,Zhao ^[6] ; Neda,Zarrin-Khameh ^[7] ; Adriana,Paulucci-Holthauzen ^[1] ; Brian W,Simons ^[8] ; Ju-Seog,Lee ^[9] ; Scott,Kopetz ^[10] ; Jihye,Yun ^[11]

作者单位： Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. ^[2] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[3] Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[4] Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[5] Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA. ^[6] Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA. ^[7] Center for Comparative Medicine, Baylor College of Medicine, Houston, TX, USA. ^[8] Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[9] Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[10] Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jyun@mdanderson.org. ^[11]

医学主题词结直肠肿瘤(Colorectal Neoplasms);果糖(Fructose);葡萄糖(Glucose);人类(Humans);动物(Animals);肿瘤转移(Neoplasm Metastasis);细胞运动(Cell Movement);小鼠(Mice);细胞系, 肿瘤(Cell Line, Tumor);糖酵解(Glycolysis);NAD(NAD)

DOI 10.1038/s42255-025-01368-w

PMID 40973819

发布时间 2025-10-27

基金项目

V Sholar/V Foundation for Cancer Research (V Foundation) Pew-Stewart Scholar/Pew Charitable Trusts R21CA258134/U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA262437/U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)

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Nature metabolism

2025年7卷10期

2018-2032页

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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD.

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Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD.

Nature metabolism

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