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Predictors of response and rational combinations for the novel MCL-1 inhibitor MIK665 in acute myeloid leukemia.

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第一作者： Joseph,Saad

第一单位： Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Finland.

作者： Joseph,Saad ^[1] ; Rhiannon,Newman ^[1] ; Elmira,Khabusheva ^[1] ; Sofia,Aakko ^[1] ; Eric,Durand ^[2] ; Mahesh,Tambe ^[1] ; Heikki,Kuusanmäki ^[1] ; Alun,Parsons ^[1] ; Juho J,Miettinen ^[1] ; Komal Kumar,Javarappa ^[3] ; Ezgi June,Olgac ^[1] ; Nemo,Ikonen ^[1] ; Mika,Kontro ^[4] ; Kimmo,Porkka ^[5] ; Heiko,Maacke ^[2] ; Janghee,Woo ^[6] ; Ensar,Halilovic ^[7] ; Caroline A,Heckman ^[1]

作者单位： Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Finland. ^[1] Novartis Biomedical Research, Basel, Switzerland. ^[2] Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Finland.;JSS Academy of Higher Education and Research (JSS AHER), University Sophisticated Instrumentation Center (USIC), Mysuru, India. ^[3] Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Finland.;Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Finland.;Foundation for the Finnish Cancer Institute, Helsinki, Finland. ^[4] Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Finland. ^[5] Winship Cancer Institute of Emory University, Atlanta, GA, USA. ^[6] Novartis Biomedical Research, Cambridge, MA, USA. ^[7]

关键词 MCL‐1 inhibition acute myeloid leukemia apoptosis combination therapies multidrug resistance‐associated proteins prognostic biomarkers

DOI 10.1002/1878-0261.70130

PMID 40975877

发布时间 2025-09-21

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