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A dynamic model for Waddington's landscape accounting for cell-to-cell communication.

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第一作者： Simon,Merkt

第一单位： Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Str. 31, Bonn, 53115, North Rhine-Westphalia, Germany; Bonn Center for Mathematical Life Sciences, University of Bonn, Endenicher Allee 64, Bonn, 53115, North Rhine-Westphalia, Germany.

作者： Simon,Merkt ^[1] ; Lara,Fuhrmann ^[2] ; Erika,Dudkin ^[3] ; Andreas,Schlitzer ^[4] ; Barbara,Niethammer ^[5] ; Jan,Hasenauer ^[6]

作者单位： Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Str. 31, Bonn, 53115, North Rhine-Westphalia, Germany; Bonn Center for Mathematical Life Sciences, University of Bonn, Endenicher Allee 64, Bonn, 53115, North Rhine-Westphalia, Germany. ^[1] Department of Biosystems Science and Engineering, ETH Zurich, Klingelbergstr. 48, Basel, 4056, Basel-Stadt, Switzerland; SIB Swiss Institute of Bioinformatics, Quartier Sorge - Bâtiment Amphipôle, Lausanne, 1015, Waadt, Switzerland. ^[2] Data Science, Software Competence Center Hagenberg (SCCH), Softwarepark 21, Hagenberg im Mühlkreis, 4232, Upper Austria, Austria. ^[3] Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Str. 31, Bonn, 53115, North Rhine-Westphalia, Germany. ^[4] Institute for Applied Mathematics, University of Bonn, Endenicher Allee 60, Bonn, 53115, North Rhine-Westphalia, Germany. ^[5] Life and Medical Sciences (LIMES), University of Bonn, Carl-Troll-Str. 31, Bonn, 53115, North Rhine-Westphalia, Germany; Bonn Center for Mathematical Life Sciences, University of Bonn, Endenicher Allee 64, Bonn, 53115, North Rhine-Westphalia, Germany. Electronic address: jan.hasenauer@uni-bonn.de. ^[6]

关键词 Cell-to-cell communication Dendritic cell activation Parameter estimation Population dynamics Single-cell transcriptomics data Stem cell regeneration Waddington’s landscape

医学主题词细胞间通讯(Cell Communication);模型, 生物学(Models, Biological);人类(Humans);动物(Animals);数学概念(Mathematical Concepts)

DOI 10.1016/j.mbs.2025.109537

PMID 40976482

发布时间 2025-12-04

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