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Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity.

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第一作者： Mark E,Schnute

第一单位： Medicine Design, Pfizer Inc, Cambridge, Massachusetts 02139, United States.

作者： Mark E,Schnute ^[1] ; Huixian,Wu ^[2] ; John I,Trujillo ^[2] ; Wei,Li ^[3] ; David Jonathan,Wasilko ^[2] ; Jennifer,Alley ^[3] ; Eric P,Arnold ^[2] ; Scott W,Bagley ^[2] ; Gabriel,Berstein ^[3] ; David C,Blakemore ^[2] ; Mark W,Bundesmann ^[1] ; Gary M,Chinigo ^[2] ; Chulho,Choi ^[2] ; Robert,Cooke ^[4] ; Kimberly,Crouse ^[3] ; Alpay,Dermenci ^[2] ; Theresa,Dickinson ^[2] ; Andrew,Flick ^[2] ; Richard K,Frisbie ^[2] ; Carmen,Garcia-Irizarry ^[2] ; Brian S,Gerstenberger ^[1] ; David,Hepworth ^[1] ; Neelu,Kaila ^[1] ; Daniel W,Kung ^[2] ; Daniel,Lamb ^[4] ; Sophie Y,Lavergne ^[2] ; David C,Limburg ^[2] ; Shenping,Liu ^[2] ; Vincent M,Lombardo ^[2] ; Prolay K,Mondal ^[2] ; James J,Mousseau ^[2] ; Arjun,Narayanan ^[1] ; Nootaree,Niljianskul ^[2] ; Philippe,Nuhant ^[2] ; Senliang,Pan ^[2] ; Michael J,Primiano ^[3] ; Mathieu,Rappas ^[4] ; Daniel C,Schmitt ^[2] ; Stefanus J,Steyn ^[1] ; Ray,Unwalla ^[1] ; Dipy,Vasa ^[5] ; Michael L,Vazquez ^[1] ; Fabien,Vincent ^[2] ; Xiaojing,Yang ^[2] ; Atli,Thorarensen ^[1]

作者单位： Medicine Design, Pfizer Inc, Cambridge, Massachusetts 02139, United States. ^[1] Medicine Design, Pfizer Inc, Groton, Connecticut 06340, United States. ^[2] Inflammation and Immunology Research, Pfizer Inc, Cambridge, Massachusetts 02139, United States. ^[3] Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom. ^[4] Drug Product Design, Pfizer Inc, Cambridge, Massachusetts 02139, United States. ^[5]