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A pH-sensitive binding modality allows successful transferrin receptor-mediated transcytosis of a bivalent antibody across brain barriers.

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第一作者： Philipp,Kuhn

第一单位： YUMAB GmbH, Braunschweig, Germany.

作者： Philipp,Kuhn ^[1] ; Sabrina,Petralla ^[2] ; Fatemeh,Dabbagh ^[3] ; Valentina,Pegoretti ^[4] ; Walter,Muranyi ^[3] ; Hiroshi,Ishikawa ^[5] ; Horst,Schroten ^[3] ; Roman,Fischer ^[4] ; André,Frenzel ^[1] ; Thomas,Schirrmann ^[1] ; Markus,Rehm ^[6] ; Christian,Schwerk ^[3] ; Gert,Fricker ^[2] ; Roland,Kontermann ^[6] ; Gavin,Fullstone ^[7]

作者单位： YUMAB GmbH, Braunschweig, Germany. ^[1] Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany. ^[2] Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ^[3] Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany. ^[4] Laboratory Clinical Regenerative Medicine, Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, Japan. ^[5] Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.;Stuttgart Research Centre for Systems Biology (SRCSB), Stuttgart, Germany. ^[6] Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.;Stuttgart Research Centre for Systems Biology (SRCSB), Stuttgart, Germany.;School of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK. ^[7]

关键词 Antibody engineering CNS-delivery bivalent brain barrier pH-sensitivity transcytosis transferrin receptor