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Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery.

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第一作者： Margarida,Cochicho Leonardo

第一单位： Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.

作者： Margarida,Cochicho Leonardo ^[1] ; Sonaly Lima,Albino ^[2] ; Wallyson Junio Santos,de Araújo ^[3] ; Maria Verônica de Barros,Nascimento ^[3] ; Juan David,Rodríguez-Macías ^[4] ; Edgar Alexander Marquez,Brazon ^[5] ; Ricardo Olimpio de,Moura ^[6] ; Fátima,Nogueira ^[1] ; Igor José Dos Santos,Nascimento ^[7]

作者单位： Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal. ^[1] Postgraduate Program of Pharmaceutical Sciences, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil. ^[2] Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil. ^[3] Facultad de Ciencias de la Salud, Exactas y Naturales, Universidad Libre Seccional Barranquilla, Barranquilla 080001, Colombia. ^[4] Facultad de Ciencias Básicas, Departamento de Química y Biología, Universidad del Norte, Barranquilla 081007, Colombia. ^[5] Postgraduate Program of Pharmaceutical Sciences, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil.;Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil. ^[6] Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (UNL), Rua da Junqueira 100, 1349-008 Lisbon, Portugal.;Postgraduate Program of Pharmaceutical Sciences, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil.;Drug Development and Synthesis Laboratory, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500, PB, Brazil. ^[7]

关键词 Plasmodium SUB1 SUB2 SUB3 antimalarial drugs subtilisin

DOI 10.3390/ph18091318

PMID 41011189

发布时间 2025-09-30

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