换一批Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.
第一作者：
Alessio,Cortellini
第一单位：
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy alessiocortellini@gmail.com.;Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.;Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.
作者：
Alessio,Cortellini [1]
;
Valentina,Santo [2]
;
Leonardo,Brunetti [3]
;
Edoardo,Garbo [4]
;
David J,Pinato [5]
;
Giulia,La Cava [6]
;
Jarushka,Naidoo [7]
;
Artur,Katz [8]
;
Monica,Loza [9]
;
Joel W,Neal [9]
;
Carlo,Genova [10]
;
Scott,Gettinger [11]
;
So Yeon,Kim [11]
;
Ritujith,Jayakrishnan [11]
;
Talal,El Zarif [11]
;
Marco,Russano [6]
;
Federica,Pecci [4]
;
Alessandro,Di Federico [4]
;
Joao V,Alessi [12]
;
Michele,Montrone [13]
;
Dwight H,Owen [14]
;
Sara,Ramella [15]
;
Diego,Signorelli [16]
;
Mary Jo,Fidler [17]
;
Mingjia,Li [18]
;
Andrea,Camerini [19]
;
Balazs,Halmos [20]
;
Bruno,Vincenzi [21]
;
Giulio,Metro [22]
;
Francesco,Passiglia [23]
;
Sai,Yendamuri [24]
;
Annalisa,Guida [25]
;
Michele,Ghidini [26]
;
Antonio,D'Alessio [27]
;
Giuseppe L,Banna [28]
;
Claudia A M,Fulgenzi [27]
;
Salvatore,Grisanti [29]
;
Francesco,Grossi [30]
;
Armida,D'Incecco [31]
;
Eleni,Josephides [32]
;
Mieke,Van Hemelrijck [33]
;
Alessandro,Russo [34]
;
Alain,Gelibter [35]
;
Gianpaolo,Spinelli [36]
;
Monica,Verrico [37]
;
Bartłomiej,Tomasik [38]
;
Raffaele,Giusti [39]
;
Kirsty,Balachandran [29]
;
Emilio,Bria [40]
;
Martin,Sebastian [32]
;
Maximilian,Rost [32]
;
Martin,Forster [41]
;
Uma,Mukherjee [41]
;
Lorenza,Landi [34]
;
Francesca,Mazzoni [35]
;
Avinash,Aujayeb [36]
;
Manuel,Dupont [37]
;
Alessandra,Curioni-Fontecedro [37]
;
Rita,Chiari [42]
;
Vincenzo,Sforza [43]
;
Marcello,Tiseo [44]
;
Alex,Friedlaender [45]
;
Alfredo,Addeo [46]
;
Federica,Zoratto [47]
;
Michele,De Tursi [48]
;
Luca,Cantini [49]
;
Elisa,Roca [50]
;
Giannis,Mountzios [51]
;
Danilo,Rocco [52]
;
Luigi,Della Gravara [52]
;
Sukumar,Kalvapudi [24]
;
Alessandro,Inno [53]
;
Paolo,Bironzo [23]
;
Rafael,Di Marco Barros [32]
;
David,O'Reilly [54]
;
Orla,Fitzpatrick [54]
;
Eleni,Karapanagiotou [32]
;
Isabelle,Monnet [55]
;
Javier,Baena [56]
;
Marianna,Macerelli [57]
;
Aida,Piedra [58]
;
Francesco,Agustoni [59]
;
Diego Luigi,Cortinovis [60]
;
Giuseppe,Tonini [21]
;
Gabriele,Minuti [34]
;
Chiara,Bennati [61]
;
Laura,Mezquita [62]
;
Teresa,Gorría [63]
;
Alberto,Servetto [64]
;
Teresa,Beninato [65]
;
Giuseppe,Lo Russo [65]
;
Arsela,Prelaj [66]
;
Andrea,De Giglio [67]
;
Jacobo,Rogado [68]
;
Laura,Moliner [69]
;
Ernest,Nadal [69]
;
Federica,Biello [70]
;
Frank Aboubakar,Nana [71]
;
Anne-Marie,Dingemans [72]
;
Joachim G J V,Aerts [72]
;
Roberto,Ferrara [73]
;
Taher,Abu Hejleh [74]
;
Kazuki,Takada [75]
;
Abdul Rafeh,Naqash [76]
;
Marina Chiara,Garassino [77]
;
Solange,Peters [78]
;
Heather A,Wakelee [9]
;
Amin H,Nassar [11]
;
Biagio,Ricciuti [4]
;
Paolo,Soda [79]
;
Camillo Maria,Caruso [80]
;
Valerio,Guarrasi [80]
作者单位：
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy alessiocortellini@gmail.com.;Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.;Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.
[1]
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.;Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
[2]
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.;Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.
[3]
Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
[4]
Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.;Translational Medicine Department, University of Eastern Piedmont, Novara, Italy.
[5]
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
[6]
Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.;RCSI University of Health Sciences, Dublin, Ireland.;Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA.
[7]
Oncology Center, Hospital Sírio-Libanês, São Paulo, SP, Brazil.
[8]
Department of Medicine, Division of Oncology, Stanford University, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
[9]
Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
[10]
Section of Medical Oncology, Department of Internal Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
[11]
Lowe Center for Thoracic Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
[12]
Medical Thoracic Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
[13]
Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.;Pelotonia Institute for Immuno-Oncology, OSUCCC - James, The Ohio State University, Columbus, OH, USA.
[14]
Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.;Operative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
[15]
Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
[16]
Division of Hematology/Oncology/Stem cell transplant, Rush University Medical Center, Chicago, IL, USA.
[17]
Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
[18]
Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy.
[19]
Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
[20]
Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.;Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
[21]
Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliero-Universitaria di Perugia, Perugia, Italy.
[22]
Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, Turin, Italy.
[23]
Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
[24]
SC Oncologia Medica e Traslazionale, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy.
[25]
Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
[26]
Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, London, UK.
[27]
Department of Oncology, Portsmouth Hospitals University NHS Trust, Portsmouth, Portsmouth, UK.
[28]
Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK.
[29]
Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
[30]
Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.
[31]
Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.
[32]
Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
[33]
Clinical Trials Center: Phase 1 and Precision Medicine, IRCCS National Cancer Institute Regina Elena, Rome, Italy.
[34]
Department of Oncology, Careggi University Hospital, Florence, Italy.
[35]
Department of Respiratory Medicine, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK.
[36]
Clinic of Oncology, Cantonal Hospital Fribourg, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
[37]
Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
[38]
Medical Oncology Unit, Sant'Andrea Hospital, Roma, Italy.
[39]
Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.;Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.
[40]
The UCL Cancer Institute, University College London Hospitals NHS Trust, London, UK.
[41]
UOC Oncologia, AST Pesaro Urbino, Pesaro, Italy.
[42]
Thoracic Medical Oncology, Istituto Nazionale Tumori, IRCCS "Fondazione G. Pascale", Naples, Italy.
[43]
Department of Medicine and Surgery, University of Parma, Parma, Italy.;Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
[44]
Clinique Générale Beaulieu, Geneva, Switzerland.
[45]
Oncology Service, University Hospital of Geneva, Geneva, Switzerland.
[46]
Medical Oncology, Ospedale Santa Maria Goretti, Latina, Lazio, Italy.
[47]
Department of Innovative Technologies in Medicine & Dentistry, University G. D'Annunzio, Chieti-Pescara, Chieti, Italy.
[48]
Fortrea Inc, Durham, North Carolina, USA.
[49]
Oncologia Toracica - Lung Unit, Ospedale P. Pederzoli, Peschiera del Garda, Italy.
[50]
4th Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece.
[51]
Department of Pulmonary Oncology, AORN dei Colli Monaldi, Naples, Italy.
[52]
Medical Oncology Unit, IRCCS Ospedale Sacro Cuore Don Calabria, Negrar di Valpolicella, Italy.
[53]
Department of Oncology, Beaumont Hospital, Beaumont RCSI Cancer Centre, Dublin, Ireland.
[54]
Service de Pneumologie, Centre Hospitalier Intercommunal, Creteil, France.
[55]
Hospital Universitario 12 de Octubre, Madrid, Spain.
[56]
Department of Oncology, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy.
[57]
Department of Medical Oncology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
[58]
Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
[59]
Division of Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori di Monza, Monza, Italy.;Department of Clinical Medicine, University of Milano-Bicocca, Milano, Italy.
[60]
Oncology Unit, Santa Maria delle Croci Hospital Ravenna, AUSL della Romagna, Ravenna, Italy.
[61]
Medical Oncology Department, Hospital Clinic de Barcelona, Barcelona, Spain.;Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.
[62]
Department of Medical Oncology, Hospital Clinic, Barcelona, Spain.
[63]
Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
[64]
Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
[65]
Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.;Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milan, Italy.
[66]
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
[67]
Medical Oncology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.
[68]
Department of Medical Oncology, Catalan Institute of Oncology (ICO) L'Hospitalet, Barcelona, Spain.
[69]
Translational Medicine Department, University of Eastern Piedmont, Novara, Italy.
[70]
Division of Pneumology, Cliniques Universitaires St-Luc, UCLouvain, Brussels, Belgium.
[71]
Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, Netherlands.
[72]
Università Vita-Salute San Raffaele, Milano, Italy.;Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.
[73]
Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan.;Department of Internal Medicine, Hematology, Oncology and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA, USA.
[74]
Department of Surgery, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
[75]
Medical Oncology/TSET Phase 1 Program, The University of Oklahoma Stephenson Cancer Center, Oklahoma City, Oklahoma, USA.
[76]
Thoracic Oncology Program, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
[77]
Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland.
[78]
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.;Department of Diagnostics and Intervention, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden.
[79]
Research Unit of Computer Systems and Bioinformatics, Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.
[80]
医学主题词
人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);肺肿瘤(Lung Neoplasms);男(雄)性(Male);女(雌)性(Female);预后(Prognosis);登记(Registries);中年人(Middle Aged);老年人(Aged);人工智能(Artificial Intelligence);老年人, 80以上(Aged, 80 and over)
DOI
10.1136/jitc-2025-012423
PMID
41022528
发布时间
2025-10-02
- 浏览1
Journal for immunotherapy of cancer
Journal for immunotherapy of cancer
2025年13卷9期
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