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Intradiscal injection of allogeneic bone marrow derived clonal mesenchymal stromal cells in discogenic low back pain: a phase I study on safety and feasibility (RELIEF: phase I).

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第一作者: Alireza Beheshti,Maal
第一单位: Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
作者单位: Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. [1] Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. ramin_kordi@tums.ac.ir.;Spine Center of Excellence, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran. ramin_kordi@tums.ac.ir. [2] Spine Center of Excellence, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.;Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. [3] Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.;Spine Center of Excellence, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran. [4] Mehregan Pain Clinic, Tehran, Iran. [5] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. [6] Department of Diagnostic Imaging, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [7] Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.;Advanced Therapy Medicinal Product Technology Development Center (ATMP-TDC), Royan Institute for Stromal Cell Biology and Technology, ACECR, Tehran, Iran. [8] Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.;Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran. [9] Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. masvos@royaninstitute.org.;Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran. masvos@royaninstitute.org. [10]
DOI 10.1186/s13287-025-04606-w
PMID 41024309
发布时间 2025-10-02
基金项目
Royesh Venture Capital/
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Stem cell research & therapy

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